Mechanisms of sleep-wake cycle modulation.

  title={Mechanisms of sleep-wake cycle modulation.},
  author={Eric Murillo-Rodr{\'i}guez and Oscar Arias-Carri{\'o}n and Katya Sanguino-Rodr{\'i}guez and Mauricio Gonz{\'a}lez-Arias and Reyes Haro},
  journal={CNS & neurological disorders drug targets},
  volume={8 4},
Regulation of the sleep-waking cycle is complex, involving multiple neurological circuits and diverse endogenous molecules. Interplay among assorted neuroanatomical and neurochemical systems such as acetylcholine, dopamine, noradrenaline, serotonin, histamine, and hypocretin maintain the waking (W) state. The sleep-onset is governed by the interacting forces of the sleep drive, which steadily increases with duration of W, and circadian fluctuations. Sleep-promoting neurons located in the… CONTINUE READING
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