Mechanisms of serotonin-induced Ca2+ responses in mesangial cells

  title={Mechanisms of serotonin-induced Ca2+ responses in mesangial cells},
  author={Margarete Goppelt-Struebe and Martin Stroebel},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
Smooth muscle cell-like mesangial cells play an important role in the regulation of glomerular blood flow and are involved in renal inflammatory reactions, thereby interacting with circulating cells. The platelet products serotonin (5-HT) and ATP induce similar, e.g. mitogenic, effects in mesangial cells, but differentially activate and induce inflammation-related genes. To get an insight into intracellular signaling steps, a very early step in the signaling cascade, the biphasic Ca2+ signal… CONTINUE READING


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