Mechanisms of sepsis-induced organ dysfunction

  title={Mechanisms of sepsis-induced organ dysfunction},
  author={E. Abraham and M. Singer},
  journal={Critical Care Medicine},
  • E. Abraham, M. Singer
  • Published 2007
  • Medicine
  • Critical Care Medicine
  • Background:The past several years have seen remarkable advances in understanding the basic cellular and physiologic mechanisms underlying organ dysfunction and recovery relating to sepsis. Although several new therapeutic approaches have improved outcome in septic patients, the far-reaching potential of these new insights into sepsis-associated mechanisms is only beginning to be realized. Aim:The Brussels Round Table Conference in 2006 convened >30 experts in the field of inflammation and… CONTINUE READING

    Topics from this paper.

    The role of mitochondrial dysfunction in sepsis-induced multi-organ failure
    • 249
    Severe sepsis in cirrhosis
    • 342
    • PDF
    Mechanisms of cardiac and renal dysfunction in patients dying of sepsis.
    • 282
    • PDF
    Survival in critical illness is associated with early activation of mitochondrial biogenesis.
    • 266
    • PDF
    Histopathology of septic shock induced acute kidney injury: apoptosis and leukocytic infiltration
    • 231
    • PDF


    Publications referenced by this paper.
    The pathophysiology and treatment of sepsis.
    • 3,551
    • PDF
    The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome.
    • 924
    • Highly Influential
    • PDF
    Reversing established sepsis with antagonists of endogenous high-mobility group box 1
    • 1,038
    • PDF
    Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction.
    • 1,154
    TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
    • 1,981
    Neutrophils in development of multiple organ failure in sepsis
    • 517