Mechanisms of selection and differentiation in germinal centers.

  title={Mechanisms of selection and differentiation in germinal centers.},
  author={Yong Jun Liu and Odette de Bouteiller and Isabelle Fugier-Vivier},
  journal={Current opinion in immunology},
  volume={9 2},
The choice between death and survival, a feature of early B cell development, is a choice also faced by mature B cells. If they survive this early developmental decision, mature B cells then face a second choice: either to undergo either terminal differentiation into plasma cells or to differentiate into memory B cells. Antigens, T cell signals (cytokines, CD40 ligand and Fas ligand) as well as the activation state of B cells determine their ultimate fate.