Mechanisms of reversible GABAA receptor plasticity after ethanol intoxication.

@article{Liang2007MechanismsOR,
  title={Mechanisms of reversible GABAA receptor plasticity after ethanol intoxication.},
  author={Jing Liang and Asha Suryanarayanan and Alana Abriam and Bradley Snyder and Richard W. Olsen and Igor Spigelman},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 45},
  pages={12367-77}
}
The time-dependent effects of ethanol (EtOH) intoxication on GABA(A) receptor (GABA(A)R) composition and function were studied in rats. A cross-linking assay and Western blot analysis of microdissected CA1 area of hippocampal slices obtained 1 h after EtOH intoxication (5 g/kg, gavage), revealed decreases in the cell-surface fraction of alpha4 and delta, but not alpha1, alpha5, or gamma2 GABA(A)R subunits, without changes in their total content. This was accompanied (in CA1 neuron recordings… CONTINUE READING

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