Mechanisms of restriction of viral neuroinvasion at the blood-brain barrier.

  title={Mechanisms of restriction of viral neuroinvasion at the blood-brain barrier.},
  author={Jonathan J Miner and Michael S Diamond},
  journal={Current opinion in immunology},
The blood-brain barrier (BBB) consists of highly specialized cells including brain microvascular endothelial cells, astrocytes, microglia, pericytes, and neurons, which act in concert to restrict the entry of pathogens, immune cells, and soluble molecules into the central nervous system (CNS). If pathogens manage to cross the BBB and establish infection within the CNS, the BBB can open in a regulated manner to allow leukocyte transmigration into the CNS so that microbes, infected cells, and… CONTINUE READING
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DB: Viral diseases of the central nervous system

  • Swanson PA, McGavern
  • Curr Opin Virol
  • 2015
1 Excerpt

Interferon - l restricts West Nile virus neuroinvasion by tightening the blood – brain barrier

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  • Sci Transl Med
  • 2015

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