Mechanisms of response to treatment in autoimmune thrombocytopenic purpura.

  title={Mechanisms of response to treatment in autoimmune thrombocytopenic purpura.},
  author={Terry Gernsheimer and John R. Stratton and Penny J Ballem and Sherrill J. Slichter},
  journal={The New England journal of medicine},
  volume={320 15},
To determine the mechanisms of an increase in the platelet count after therapy for autoimmune thrombocytopenic purpura, we determined the survival time and localization of radiolabeled autologous platelets and measured platelet-associated immunoglobulin levels before and after prednisone therapy or splenectomy in 19 patients with the disease. Eleven of 12 patients (92 percent) responded to prednisone with a mean threefold increase in the platelet count, resulting from increased platelet… CONTINUE READING
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