Mechanisms of respiratory tissue injury from cigarette smoking.

  title={Mechanisms of respiratory tissue injury from cigarette smoking.},
  author={Kevin McCusker},
  journal={The American journal of medicine},
  volume={93 1A},
Cigarette smoking can be viewed as a chronic inflammatory disorder of the lower airways. Two of the major lung injuries that can result are chronic bronchitis and emphysema. Chronic bronchitis is characterized by chronic mucus hypersecretion and cough; emphysema is a destructive process of the alveolar spaces. Tissue injury may result from the actions of degradative enzymes derived from such inflammatory cells as neutrophils and monocytes. In addition, oxidative injury from inflammatory cells… CONTINUE READING
Highly Cited
This paper has 29 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 13 extracted citations

Metalloelastase in lungs and alveolar macrophages is modulated by extracellular substance P in mice.

American journal of physiology. Lung cellular and molecular physiology • 2008
View 7 Excerpts
Highly Influenced

Methods of in vitro toxicology.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association • 2002
View 2 Excerpts