Mechanisms of resistance to structurally diverse antiestrogens differ under premenopausal and postmenopausal conditions: evidence from in vitro breast cancer cell models.

@article{Fan2009MechanismsOR,
  title={Mechanisms of resistance to structurally diverse antiestrogens differ under premenopausal and postmenopausal conditions: evidence from in vitro breast cancer cell models.},
  author={Ping Fan and Wei Ping Yue and Ji-Ping Z. Wang and Sarah E. Aiyar and Yan Li and Tae Hyun Kim and Richard J. Santen},
  journal={Endocrinology},
  year={2009},
  volume={150 5},
  pages={2036-45}
}
This study questioned whether the mechanisms of resistance to antiestrogens differ when acquired under premenopausal (Pre-M) vs. postmenopausal (PM) conditions and whether structurally diverse antiestrogens induce adaptation of differing signaling pathways. To address this issue, we conducted systematic studies under Pre-M vs. PM culture conditions with long-term exposure to different antiestrogens and examined the resultant "specific biologic signatures" of the various resistant cells… CONTINUE READING

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