Mechanisms of resistance to methotrexate in childhood acute lymphoblastic leukemia: circumvention of thymidylate synthase inhibition

Abstract

Purpose: In about 25% of patients suffering from acute lymphoblastic leukemia (ALL) treatment failures occur that are most likely due to development of resistance to methotrexate (MTX). Blasts from patients with ALL were evaluated for MTX uptake, formation of long-chain MTX polyglutamates (MTX-Glu5+6), cytotoxicity and thymidylate synthase inhibition by MTX… (More)
DOI: 10.1007/s004320050310

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@article{Weigand1999MechanismsOR, title={Mechanisms of resistance to methotrexate in childhood acute lymphoblastic leukemia: circumvention of thymidylate synthase inhibition}, author={Melanie Weigand and Eva Frei and Nicole Graf and Bruno Buchholz and Claire M. Wolfrom and Annette Breuer and Manfred Wiessler}, journal={Journal of Cancer Research and Clinical Oncology}, year={1999}, volume={125}, pages={513-519} }