Mechanisms of resistance to imipenem and ampicillin in Enterococcus faecalis.

  title={Mechanisms of resistance to imipenem and ampicillin in Enterococcus faecalis.},
  author={Seiji Ono and Tetsuro Muratani and Tetsuro Matsumoto},
  journal={Antimicrobial agents and chemotherapy},
  volume={49 7},
We found ampicillin- and imipenem-resistant isolates of vanA-possessing Enterococcus faecalis with MICs of 8 to 16 microg/ml and 4 to 32 microg/ml, respectively. There have been few reports about penicillin- and imipenem-resistant E. faecalis. Two mechanisms of beta-lactam resistance in E. faecalis, the production of beta-lactamase and the overproduction of penicillin-binding proteins (PBPs), have been reported. The resistant isolates in the current study did not produce any beta-lactamases and… CONTINUE READING
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