Mechanisms of resistance to fluoroquinolones in Coxiella burnetii.


Mechanisms of resistance to quinolones were investigated in two in vitro DNA gyrase mutant Coxiella burnetii strains. Accumulation of pefloxacin was found to be lower in resistant strains than in susceptible strains. Pre-incubation with carbonyl cyanide m-chlorophenylhydrazone had no apparent effect on intracellular quinolone fluorescence, indicating that… (More)


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@article{Spyridaki2002MechanismsOR, title={Mechanisms of resistance to fluoroquinolones in Coxiella burnetii.}, author={Ioanna Spyridaki and Anna Psaroulaki and Emmanouil Kokkinakis and Achilleas I Gikas and Yannis J Tselentis}, journal={The Journal of antimicrobial chemotherapy}, year={2002}, volume={49 2}, pages={379-82} }