Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.

@article{Sanglard1995MechanismsOR,
  title={Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.},
  author={Dominique Sanglard and Karl Kuchler and Françoise Ischer and Joanne Pagani and Michel Monod and Jacques Bille},
  journal={Antimicrobial agents and chemotherapy},
  year={1995},
  volume={39 11},
  pages={
          2378-86
        }
}
Azole antifungal agents, and especially fluconazole, have been used widely to treat oropharyngeal candidiasis in patients with AIDS. An increasing number of cases of clinical resistance against fluconazole, often correlating with in vitro resistance, have been reported. To investigate the mechanisms of resistance toward azole antifungal agents at the molecular level in clinical C. albicans isolates, we focused on resistance mechanisms related to the cellular target of azoles, i.e., cytochrome… CONTINUE READING

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Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals

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