Mechanisms of resistance to azacitidine in human leukemia cell lines.

@article{Sripayap2014MechanismsOR,
  title={Mechanisms of resistance to azacitidine in human leukemia cell lines.},
  author={Piyanuch Sripayap and T. Nagai and Mitsuyo Uesawa and Hiroyuki Kobayashi and T. Tsukahara and K. Ohmine and K. Muroi and K. Ozawa},
  journal={Experimental hematology},
  year={2014},
  volume={42 4},
  pages={
          294-306.e2
        }
}
The DNA methylation inhibitor azacitidine (5-azacytidine) is used against myelodysplastic syndrome and acute myeloid leukemia, but drug resistance is an ongoing, intractable problem. To investigate resistance mechanisms, we generated two azacitidine-resistant cell lines, THP-1/AR and HL60/AR, and studied genetic disparities between them and their corresponding parental lines. In cells treated with azacitidine, significant mitotic variations were noted in parental cells which were absent in… Expand
5-Azacitidine induces demethylation of PTPL1 and inhibits growth in non-Hodgkin lymphoma
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