Mechanisms of resistance to TRAIL-induced apoptosis in cancer

@article{Zhang2005MechanismsOR,
  title={Mechanisms of resistance to TRAIL-induced apoptosis in cancer},
  author={Lidong Zhang and Bingliang Fang},
  journal={Cancer Gene Therapy},
  year={2005},
  volume={12},
  pages={228-237}
}
The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is regarded as a potential anticancer agent. However, considerable numbers of cancer cells, especially some highly malignant tumors, are resistant to apoptosis induction by TRAIL, and some cancer cells that were originally sensitive to TRAIL-induced apoptosis can become resistant after repeated exposure (acquired resistance). Understanding the mechanisms underlying such resistance and developing strategies to overcome it are… CONTINUE READING
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