Mechanisms of reprogrammed macrophage endotoxin signal transduction after lipopolysaccharide pretreatment.

@article{West1995MechanismsOR,
  title={Mechanisms of reprogrammed macrophage endotoxin signal transduction after lipopolysaccharide pretreatment.},
  author={Mike West and Susan C Seatter and James Bellingham and Luke St. Clair},
  journal={Surgery},
  year={1995},
  volume={118 2},
  pages={220-8}
}
BACKGROUND Dysregulation of macrophage tumor necrosis factor (TNF) and interleukin-(IL-1) release results from repetitive lipopolysacharride (LPS) stimulation. In this study we investigated the mechanisms of LPS pretreatment (LPSp) signal transduction producing altered LPS-activated (LPSa) cytokine release. METHODS Murine macrophages were treated with medium alone, actinomycin D, cycloheximide, a protein kinase C inhibitor (H7), or the nitric oxide synthase inhibitor L-NMA. Macrophages were… CONTINUE READING
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