Mechanisms of replication and repair in mitochondrial DNA deletion formation

@article{Fontana2020MechanismsOR,
  title={Mechanisms of replication and repair in mitochondrial DNA deletion formation},
  author={Gabriele A Fontana and Hailey L Gahlon},
  journal={Nucleic Acids Research},
  year={2020},
  volume={48},
  pages={11244 - 11258}
}
Abstract Deletions in mitochondrial DNA (mtDNA) are associated with diverse human pathologies including cancer, aging and mitochondrial disorders. Large-scale deletions span kilobases in length and the loss of these associated genes contributes to crippled oxidative phosphorylation and overall decline in mitochondrial fitness. There is not a united view for how mtDNA deletions are generated and the molecular mechanisms underlying this process are poorly understood. This review discusses the… 

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