Mechanisms of rejection: role of complement.

  title={Mechanisms of rejection: role of complement.},
  author={Conrad A. Farrar and Steven H Sacks},
  journal={Current opinion in organ transplantation},
  volume={19 1},
PURPOSE OF REVIEW To provide the reader with an up-to-date comprehensive review of recent findings that highlight advances describing how proteins of the complement cascades contribute to the pathogenesis of solid organ rejection. The review is focussed mainly on renal transplantation. RECENT FINDINGS Of note are recent advances in elucidating the interactions between anaphylatoxins and their receptors in organ transplantation; there is evidence of direct engagement of C5aR on donor tubules… CONTINUE READING

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