Mechanisms of rejection: current perspectives.

@article{Wood2012MechanismsOR,
  title={Mechanisms of rejection: current perspectives.},
  author={Kathryn J. Wood and Ryoichi Goto},
  journal={Transplantation},
  year={2012},
  volume={93 1},
  pages={
          1-10
        }
}
Rejection is the major barrier to successful transplantation. The immune response to an allograft is an ongoing dialogue between the innate and adaptive immune system that if left unchecked will lead to the rejection of transplanted cells, tissues, or organs. Activation of elements of the innate immune system, triggered as a consequence of tissue injury sustained during cell isolation or organ retrieval and ischemia reperfusion, will initiate and amplify the adaptive response. T cells require a… CONTINUE READING

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