Mechanisms of regulating the Raf kinase family.

  title={Mechanisms of regulating the Raf kinase family.},
  author={Huira Chong and Haris G. Vikis and Kun Liang Guan},
  journal={Cellular signalling},
  volume={15 5},
The MAP Kinase pathway is a key signalling mechanism that regulates many cellular functions such as cell growth, transformation and apoptosis. One of the essential components of this pathway is the serine/threonine kinase, Raf. Raf (MAPKK kinase, MAPKKK) relays the extracellular signal from the receptor/Ras complex to a cascade of cytosolic kinases by phosphorylating and activating MAPK/ERK kinase (MEK; MAPK kinase, MAPKK) that phosphorylates and activates extracellular signal regulated kinase… CONTINUE READING
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