Mechanisms of reduced striatal NMDA excitotoxicity in type I nitric oxide synthase knock-out mice.

@article{Ayata1997MechanismsOR,
  title={Mechanisms of reduced striatal NMDA excitotoxicity in type I nitric oxide synthase knock-out mice.},
  author={Cenk Ayata and Gamze Ayata and Hideaki Hara and Russell Thomas Matthews and Michael Beal and Robert Ferrante and Matthias Endres and A Kim and Richard H. Christie and Christian Waeber and Paul Lee Huang and Bradley T. Hyman and Michael A. Moskowitz},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1997},
  volume={17 18},
  pages={6908-17}
}
We investigated the role of neuronal (type I) nitric oxide synthase (nNOS) in NMDA-mediated excitotoxicity in wild-type (SV129 and C57BL/6J) and type I NOS knock-out (nNOS-/-) mice and examined its relationship to apoptosis. Excitotoxic lesions were produced by intrastriatal stereotactic NMDA microinjections (10-20 nmol). Lesion size was dose- and time-dependent, completely blocked by MK-801 pretreatment, and smaller in nNOS knock-out mice compared with wild-type littermates (nNOS+/+, 11.7… CONTINUE READING