Mechanisms of reduced maternal and fetal lopinavir exposure in a rat model of gestational diabetes.

@article{Anger2011MechanismsOR,
  title={Mechanisms of reduced maternal and fetal lopinavir exposure in a rat model of gestational diabetes.},
  author={Gregory J. Anger and Micheline Piquette-Miller},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2011},
  volume={39 10},
  pages={1850-9}
}
Lopinavir (LPV) is the preferred HIV protease inhibitor in pregnancy, but it is unknown if gestational diabetes mellitus (GDM) affects its disposition. Hepatic protein expression and plasma protein binding are altered in rodent models of GDM. Because LPV is influenced by hepatic transporters and metabolic enzymes and is highly protein bound, it was hypothesized that streptozotocin-induced GDM would alter its disposition. Maternal and fetal tissues were collected from GDM rats and controls 45… CONTINUE READING