Mechanisms of receptor-mediated rhinovirus neutralization defined by two soluble forms of ICAM-1.

@article{Greve1991MechanismsOR,
  title={Mechanisms of receptor-mediated rhinovirus neutralization defined by two soluble forms of ICAM-1.},
  author={J M Greve and Carla P. Forte and Christopher W Marlor and andD. M. Meyer and Helana Hoover-Litty and Dirk Wunderlich and Alan McClelland},
  journal={Journal of virology},
  year={1991},
  volume={65 11},
  pages={6015-23}
}
The majority of human rhinoviruses use intercellular adhesion molecule 1 (ICAM-1) as a cell surface receptor. Two soluble forms of ICAM-1, one corresponding to the entire extracellular portion [tICAM(453)] and one corresponding to the two N-terminal immunoglobulin-like domains [tICAM(185)], have been produced, and their effects on virus-receptor binding, virus infectivity, and virus integrity have been examined. Results from competitive binding experiments indicate that the virus binding site… CONTINUE READING

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Three-dimensional structure of immunoglobulins

L. M. Amzel, R. J. Poijak
Annu. Rev. Biochem • 1979

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