Mechanisms of reactive oxygen species-dependent downregulation of insulin receptor substrate-1 by angiotensin II.


OBJECTIVE Angiotensin II has been implicated in the pathogenesis of the vascular complications of insulin resistance. Recently, serine phosphorylation and degradation of insulin receptor substrate-1 (IRS-1) were shown to inhibit Akt activation and reduce glucose uptake. Therefore, we examined the effects of chronic angiotensin II treatment on IRS-1… (More)

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