Mechanisms of rapid sensory hair-cell death following co-administration of gentamicin and ethacrynic acid

@article{Ding2010MechanismsOR,
  title={Mechanisms of rapid sensory hair-cell death following co-administration of gentamicin and ethacrynic acid},
  author={Dalian Ding and Haiyan Jiang and Richard J. Salvi},
  journal={Hearing Research},
  year={2010},
  volume={259},
  pages={16-23}
}
Concurrent administration of a high dose of gentamicin (GM; 125mg/kg IM) and ethacrynic acid (EA; 40mg/kg IV) results in rapid destruction of virtually all cochlear hair cells; however, the cell death signaling pathways underlying this rapid form of hair-cell degeneration are unclear. To elucidate the mechanisms underlying GM/EA-mediated cell death, several key cell death markers were assessed in the chinchilla cochlea during the early stages of degeneration. In the middle and basal turns of… CONTINUE READING
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