Mechanisms of radiotherapy-associated cognitive disability in patients with brain tumours

@article{Makale2017MechanismsOR,
  title={Mechanisms of radiotherapy-associated cognitive disability in patients with brain tumours},
  author={Milan T. Makale and Carrie R. McDonald and Jona A. Hattangadi-Gluth and Santosh Kesari},
  journal={Nature Reviews Neurology},
  year={2017},
  volume={13},
  pages={52-64}
}
Standard treatment of primary and metastatic brain tumours includes high-dose megavoltage-range radiation to the cranial vault. About half of patients survive >6 months, and many attain long-term control or cure. However, 50–90% of survivors exhibit disabling cognitive dysfunction. The radiation-associated cognitive syndrome is poorly understood and has no effective prevention or long-term treatment. Attention has primarily focused on mechanisms of disability that appear at 6 months to 1 year… CONTINUE READING
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