Mechanisms of radical formation from reactions of ozone with target molecules in the lung.

@article{Pryor1994MechanismsOR,
  title={Mechanisms of radical formation from reactions of ozone with target molecules in the lung.},
  author={William A. Pryor},
  journal={Free radical biology & medicine},
  year={1994},
  volume={17 5},
  pages={451-65}
}
Ozone is known to cause radicals to be formed in biological systems: for example, it initiates lipid peroxidation and vitamin E protects in vitro model systems, cells, and animals against the effects of ozone. Ozone is not itself a radical, and we have asked: With what molecules does ozone react in the lung and how are radicals produced? Ozone reacts by two quite different mechanisms to produce radicals; one involves an ozone-olefin reaction and the other a reaction with electron donors such as… CONTINUE READING
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