Mechanisms of radiation-induced sensorineural hearing loss and radioprotection.

@article{MujicaMota2014MechanismsOR,
  title={Mechanisms of radiation-induced sensorineural hearing loss and radioprotection.},
  author={Mario A Mujica-Mota and Shirley M Lehnert and Slobodan Devic and Karina Gasbarrino and Sam Joseph Daniel},
  journal={Hearing research},
  year={2014},
  volume={312},
  pages={60-8}
}
Patients that receive radiotherapy are at risk of late sensorineural hearing loss when the inner ear is included within the radiation field. Preclinical and human temporal bone studies have shown that there is differential damage to cochlear structures depending on the amount of dose delivered to the inner ear. In vitro studies have suggested that reactive oxygen species (ROS) are the main initial actors in radiation-induced damage. The interaction of ROS with different cellular components can… CONTINUE READING