Mechanisms of quinolone phototoxicity.

@article{Shimoda1998MechanismsOQ,
  title={Mechanisms of quinolone phototoxicity.},
  author={Kohji Shimoda},
  journal={Toxicology letters},
  year={1998},
  volume={102-103},
  pages={369-73}
}
We examined the mechanisms of quinolone phototoxicity in vivo and in vitro. Simultaneous p.o. administration of a quinolone and ultraviolet-A (UVA) irradiation for 4 h induced auricular skin inflammation in BALB/c mice, including edema and neutrophil infiltration in the dermis. Antioxidants inhibited the inflammation in the early stage and cyclooxygenase inhibitors did in both the early and later stages, whereas 5-lipoxygenase inhibitors or histamine antagonists had no effect. The phototoxic… CONTINUE READING