Mechanisms of quinolone action and resistance: where do we stand?

  title={Mechanisms of quinolone action and resistance: where do we stand?},
  author={S. Correia and P. Poeta and M. H{\'e}braud and J. L. Capelo and G. Igrejas},
  journal={Journal of medical microbiology},
  volume={66 5},
  • S. Correia, P. Poeta, +2 authors G. Igrejas
  • Published 2017
  • Biology, Medicine
  • Journal of medical microbiology
  • Quinolone antibiotics represent one of the most important classes of anti-infective agents and, although still clinically valuable, their use has been compromised by the increasing emergence of resistant strains, which has become a prevalent clinical problem. Quinolones act by inhibiting the activity of DNA gyrase and topoisomerase IV - two essential bacterial enzymes that modulate the chromosomal supercoiling required for critical nucleic acid processes. The acquisition of quinolone resistance… CONTINUE READING
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