Mechanisms of pulmonary fibrosis.

  title={Mechanisms of pulmonary fibrosis.},
  author={Victor J Thannickal and Galen B. Toews and Eric S White and Joseph Pedulla Lynch and Fernando J Martinez},
  journal={Annual review of medicine},
Tissue injury evokes highly conserved, tightly regulated inflammatory responses and less well-understood host repair responses. Both inflammation and repair involve the recruitment, activation, apoptosis, and eventual clearance of key effector cells. In this review, we propose the concept of pulmonary fibrosis as a dysregulated repair process that is perpetually "turned on" even though classical inflammatory pathways may be dampened or "switched off." Significant regional heterogeneity, with… CONTINUE READING