Mechanisms of protein folding.

@article{Grantcharova2001MechanismsOP,
  title={Mechanisms of protein folding.},
  author={Viara Grantcharova and Eric John Alm and David Baker and Arthur L Horwich},
  journal={Current opinion in structural biology},
  year={2001},
  volume={11 1},
  pages={70-82}
}
The strong correlation between protein folding rates and the contact order suggests that folding rates are largely determined by the topology of the native structure. However, for a given topology, there may be several possible low free energy paths to the native state and the path that is chosen (the lowest free energy path) may depend on differences in interaction energies and local free energies of ordering in different parts of the structure. For larger proteins whose folding is assisted by… CONTINUE READING

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