Mechanisms of protein damage induced by cysteine thiyl radical formation.

  title={Mechanisms of protein damage induced by cysteine thiyl radical formation.},
  author={Christian Sch{\"o}neich},
  journal={Chemical research in toxicology},
  volume={21 6},
Oxidative post-translational modifications of proteins play an important role in modulating conformation, activity, and turnover in response to a variety of biologic stimuli (1). These modifications arise as a result of both controlled enzymatic and less-controlled nonenzymatic chemically induced processes. To date, more than 200 post-translational protein modifications are known (2), creating a vast array of possible protein isoforms when 30000 gene products have the opportunity to accumulate… CONTINUE READING
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