Mechanisms of protection against virulentYersinia pestis infection without participation of humoral antibody: H-2 restriction in athymic mouse model

@article{Wake2005MechanismsOP,
  title={Mechanisms of protection against virulentYersinia pestis infection without participation of humoral antibody: H-2 restriction in athymic mouse model},
  author={Akira Wake and Yuki Sutoh},
  journal={Current Microbiology},
  year={2005},
  volume={8},
  pages={79-84}
}
Athymic mice, deficient in mature T-lymphocytes, were killed when subcutaneously challenged with 100 organisms of a highly virulent strain ofYersinia pestis. None of the methods for activating the macrophages protected the animals from death; however, the survival time of the mice primed withYersinia pseudotuberculosis containing VW antigen 14 days before the challenge was significantly prolonged. Neither IgM nor IgG specific forY. pestis was detectable in these mice 14 days after priming. The… CONTINUE READING

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