Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes.

  title={Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes.},
  author={Giuseppe Remuzzi and Ariela Benigni and Andrea Remuzzi},
  journal={The Journal of clinical investigation},
  volume={116 2},
The incidence of chronic kidney diseases is increasing worldwide, and these conditions are emerging as a major public health problem. While genetic factors contribute to susceptibility and progression of renal disease, proteinuria has been claimed as an independent predictor of outcome. Reduction of urinary protein levels by various medications and a low-protein diet limits renal function decline in individuals with nondiabetic and diabetic nephropathies to the point that remission of the… CONTINUE READING
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