Mechanisms of progesterone receptor export from nuclei: role of nuclear localization signal, nuclear export signal, and ran guanosine triphosphate.

@article{Tyagi1998MechanismsOP,
  title={Mechanisms of progesterone receptor export from nuclei: role of nuclear localization signal, nuclear export signal, and ran guanosine triphosphate.},
  author={Rakesh Kumar Tyagi and Larbi Amazit and Pierre Lescop and Edwin Milgrom and Anne Guiochon-Mantel},
  journal={Molecular endocrinology},
  year={1998},
  volume={12 11},
  pages={1684-95}
}
Steroid hormone receptors are, in most cases, mainly nuclear proteins that undergo a continuous nucleocytoplasmic shuttling. The mechanism of the nuclear export of these proteins remains largely unknown. To approach this problem experimentally in vivo, we have prepared cell lines permanently coexpressing the wild-type nuclear progesterone receptor (PR) and a cytoplasmic receptor mutant deleted of its nuclear localization signal (NLS) [(deltaNLS)PR]. Each receptor species was deleted from the… CONTINUE READING
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