Mechanisms of polymorphonuclear leukocyte mediated peritoneal mesothelial cell injury.

@article{Andreoli1994MechanismsOP,
  title={Mechanisms of polymorphonuclear leukocyte mediated peritoneal mesothelial cell injury.},
  author={Sharon Phillips Andreoli and Coleen Mallett and Karin Williams and James A. McAteer and Robert Rothlein and Claire M Doerschuk},
  journal={Kidney international},
  year={1994},
  volume={46 4},
  pages={1100-9}
}
To determine the susceptibility of human peritoneal mesothelial cells to injury mediated by activated polymorphonuclear leukocytes (PMNs), we exposed cultured human peritoneal mesothelial cells to 1250, 2500, 3750, and 5000 PMNs/mm3 activated with 50 ng/ml phorbol myristate acetate (PMA) or with 10(-7) FMLP/cytochalasin B for one to five hours. PMN adhesion… CONTINUE READING