Mechanisms of plasmid stable maintenance with special focus on plasmid addiction systems.

@article{Zielenkiewicz2001MechanismsOP,
  title={Mechanisms of plasmid stable maintenance with special focus on plasmid addiction systems.},
  author={Urszula Zielenkiewicz and Piotr Cegłowski},
  journal={Acta biochimica Polonica},
  year={2001},
  volume={48 4},
  pages={1003-23}
}
The stable inheritance of bacterial plasmids is achieved by a number of different mechanisms. Among them are resolution of plasmid oligomers into monomers, active plasmid partitioning into dividing cells and selective killing of plasmid-free segregants. A special focus is given to the last mechanism. It involves a stable toxin and an unstable antidote. The antidotes neutralize their cognate toxins or prevent their synthesis. The different decay rates of the toxins and the antidotes underlie… CONTINUE READING