Mechanisms of phospholipase D stimulation by m3 muscarinic acetylcholine receptors. Evidence for involvement of tyrosine phosphorylation.

@article{Schmidt1994MechanismsOP,
  title={Mechanisms of phospholipase D stimulation by m3 muscarinic acetylcholine receptors. Evidence for involvement of tyrosine phosphorylation.},
  author={Michael F. Schmidt and S M H{\"u}we and B Fasselt and Dirk Homann and Ulrich R{\"u}menapp and J Sandmann and Karl Heinz Jakobs},
  journal={European journal of biochemistry},
  year={1994},
  volume={225 2},
  pages={667-75}
}
In human embryonic kidney cells stably expressing the human m3 muscarinic acetylcholine receptor (mAChR) subtype, agonist (carbachol) activation stimulated phospholipase C, increased cytoplasmic calcium concentration, induced tyrosine phosphorylation of various cellular proteins and activated phospholipase D. Bypassing membrane receptors, phospholipase D was activated in these cells by direct activation of protein kinase C by phorbol esters, by direct activation of GTP-binding proteins by A1F4… CONTINUE READING

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