Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver.

@article{Pogribny2008MechanismsOP,
  title={Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver.},
  author={Igor P Pogribny and Volodymyr P. Tryndyak and Anna Boureiko and Stepan Melnyk and Tetyana V Bagnyukova and Beverly Montgomery and Ivan Rusyn},
  journal={Mutation research},
  year={2008},
  volume={644 1-2},
  pages={17-23}
}
Genomic hypomethylation is a consistent finding in both human and animal tumors and mounting experimental evidence suggests a key role for epigenetic events in tumorigenesis. Furthermore, it has been suggested that early changes in DNA methylation and histone modifications may serve as sensitive predictive markers in animal testing for carcinogenic potency of environmental agents. Alterations in metabolism of methyl donors, disturbances in activity and/or expression of DNA methyltransferases… CONTINUE READING