Mechanisms of pathogen entry through the endosomal compartments

  title={Mechanisms of pathogen entry through the endosomal compartments},
  author={J. Gruenberg and F. Goot},
  journal={Nature Reviews Molecular Cell Biology},
  • J. Gruenberg, F. Goot
  • Published 2006
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • Several pathogens — bacteria, viruses and parasites — must enter mammalian cells for survival, replication and immune-system evasion. These pathogens generally make use of existing cellular pathways that are designed for nutrient uptake, receptor downregulation and signalling. Because most of these pathways end in lysosomes, an organelle that is capable of killing microorganisms, pathogens have developed remarkable means to avoidinteractions with this lytic organelle. 
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