Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters.

@article{Leuthold2009MechanismsOP,
  title={Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters.},
  author={Simone Leuthold and Bruno Hagenbuch and Nilufar Mohebbi and Carsten A Wagner and Peter Meier and Bruno Stieger},
  journal={American journal of physiology. Cell physiology},
  year={2009},
  volume={296 3},
  pages={C570-82}
}
Organic anion transporting polypeptides (humans OATPs, rodents Oatps) are expressed in most mammalian tissues and mediate cellular uptake of a wide variety of amphipathic organic compounds such as bile salts, steroid conjugates, oligopeptides, and a large list of drugs, probably by acting as anion exchangers. In the present study we aimed to investigate the role of the extracellular pH on the transport activity of nine human and four rat OATPs/Oatps. Furthermore, we aimed to test the concept… CONTINUE READING
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