Mechanisms of p53-dependent apoptosis.

  title={Mechanisms of p53-dependent apoptosis.},
  author={M. Schuler and D. Green},
  journal={Biochemical Society transactions},
  volume={29 Pt 6},
Cellular stresses, such as growth factor deprivation, DNA damage or oncogene expression, lead to stabilization and activation of the p53 tumour suppressor protein. Depending on the cellular context, this results in one of two different outcomes: cell cycle arrest or apoptotic cell death. Cell death induced through the p53 pathway is executed by the caspase proteinases, which, by cleaving their substrates, lead to the characteristic apoptotic phenotype. Caspase activation by p53 occurs through… Expand
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