Mechanisms of oxygen sensing: a key to therapy of pulmonary hypertension and patent ductus arteriosus.


Specialized tissues that sense acute changes in the local oxygen tension include type 1 cells of the carotid body, neuroepithelial bodies in the lungs, and smooth muscle cells of the resistance pulmonary arteries and the ductus arteriosus (DA). Hypoxia inhibits outward potassium current in carotid body type 1 cells, leading to depolarization and calcium… (More)
DOI: 10.1038/bjp.2008.291

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