Mechanisms of oxidative damage of low density lipoprotein in human atherosclerosis.

  title={Mechanisms of oxidative damage of low density lipoprotein in human atherosclerosis.},
  author={Jay W. Heinecke},
  journal={Current opinion in lipidology},
  volume={8 5},
Oxidatively damaged LDL may play a critical role in the pathogenesis of atherosclerotic vascular disease. Several pathways promote LDL oxidation in vitro but the physiologically relevant mechanisms have proven difficult to identify. Detection of stable compounds that result from specific reaction pathways has provided the first insights into the mechanism of oxidative damage in the human artery wall. Mass spectrometric analysis of protein oxidation products isolated from atherosclerotic tissue… CONTINUE READING

From This Paper

Topics from this paper.
70 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 70 extracted citations

Similar Papers

Loading similar papers…