Mechanisms of oxidative DNA damage induced by carcinogenic arylamines.

@article{Murata2011MechanismsOO,
  title={Mechanisms of oxidative DNA damage induced by carcinogenic arylamines.},
  author={Mariko Murata and Shosuke Kawanishi},
  journal={Frontiers in bioscience},
  year={2011},
  volume={16},
  pages={1132-43}
}
Most arylamines are pro-carcinogens, and require metabolic activation to yield ultimate carcinogen metabolites. O-Acetylation of the N-hydroxy form of an arylamine yields an acetoxyarylamine, which can form a highly reactive arylnitrenium ion, the ultimate metabolite responsible for DNA adduct formation. However, we demonstrate here that the N-hydroxy and nitroso forms of arylamines can also induce DNA damage, including 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-oxodG) lesions, via reactive oxygen… CONTINUE READING

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