Mechanisms of opioid-mediated inhibition of human T cell receptor signaling.

  title={Mechanisms of opioid-mediated inhibition of human T cell receptor signaling.},
  author={Christine B{\"o}rner and Beate Warnick and Michal Smida and Roland Hartig and Jonathan A. Lindquist and Burkhart Schraven and Volker Hoellt and J{\"u}rgen Kraus},
  journal={Journal of immunology},
  volume={183 2},
Opioids are widely used for the treatment of severe pain. However, it is also known that opioids, in particular morphine, cause immunosuppression. Therefore, their use may complicate treatment of persons with an already impaired immune system, e.g., patients suffering from cancer or AIDS. We investigated the mechanisms of opioid-induced immunosuppression in primary human T lymphocytes and the human T cell line Jurkat. We demonstrated that morphine and the endogenous opioid beta-endorphin… CONTINUE READING


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