Mechanisms of oncogene-mediated alterations in metastatic ability.

  title={Mechanisms of oncogene-mediated alterations in metastatic ability.},
  author={A. F. Chambers},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  volume={70 9},
  • A. F. Chambers
  • Published 1992 in
    Biochemistry and cell biology = Biochimie et…
Transfected ras oncogenes have been shown to induce metastatic properties in some cells. This altered behavior is likely due to changes in ras-mediated signal transduction pathways, resulting in altered expression of genes important to metastasis. Clarification of the mechanisms by which ras is able to induce metastatic ability in model systems will improve our understanding of tumor progression, even in those cells in which ras activation has not been implicated. Many of the consequences of… CONTINUE READING

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