Mechanisms of nuclear localization of the progesterone receptor: evidence for interaction between monomers.

@article{GuiochonMantel1989MechanismsON,
  title={Mechanisms of nuclear localization of the progesterone receptor: evidence for interaction between monomers.},
  author={Anne Guiochon-Mantel and Hugues Loosfelt and Pierre Lescop and Sokavuth Sar and Michel Atger and Martine Perrot-Applanat and Edwin Milgrom},
  journal={Cell},
  year={1989},
  volume={57 7},
  pages={1147-54}
}
Deletion mutants of the rabbit progesterone receptor were used to identify two major mechanisms of its nuclear localization. A putative signal sequence, homologous to that of the SV40 large T antigen, was localized around amino acids 638-642 and shown to be constitutively active. When amino acids 638-642 were deleted, the receptor became cytoplasmic but could be shifted into the nucleus by the addition of hormone (or anti-hormone); it was almost fully active. The second mechanism consisted of… CONTINUE READING

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