Mechanisms of noise-induced hearing loss potentiation by hypoxia

@article{Chen2005MechanismsON,
  title={Mechanisms of noise-induced hearing loss potentiation by hypoxia},
  author={Guang-di Chen and Yun Liu},
  journal={Hearing Research},
  year={2005},
  volume={200},
  pages={1-9}
}
Potentiation of noise-induced permanent threshold shift (PTS) by hypoxia has been reported [Hear. Res. 172 (1-2) (2002) 186]. In this study in rats, effects of noise (110 dB SPL), hypoxia (10% O(2)), and their combination have been determined on different cochlear potentials and on the expression of genes coding proteins in the outer hair cell (OHC) membrane skeleton (beta-actin) and in the mitochondrial respiratory chain (SDHa & b). The noise exposure alone caused CAP threshold shift only in… CONTINUE READING

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